癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC9A6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q92581 |
| Other Accession | NP_006350.1 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 77917 Da |
| Antigen Region | 501-530 aa |
| Gene ID | 10479 |
|---|---|
| Other Names | Sodium/hydrogen exchanger 6, Na(+)/H(+) exchanger 6, NHE-6, Solute carrier family 9 member 6, SLC9A6, KIAA0267, NHE6 |
| Target/Specificity | This SLC9A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 501-530 amino acids from the C-terminal region of human SLC9A6. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC9A6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC9A6 (HGNC:11079) |
|---|---|
| Synonyms | KIAA0267, NHE6 |
| Function | Endosomal Na(+), K(+)/H(+) antiporter (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (PubMed:20130086). Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity). |
| Cellular Location | Endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Present predominantly in the recycling compartments including early and recycling endosomes, but undergoes plasma membrane localization during vesicular recycling, which is enhanced upon certain stimuli, such as hypoxia (PubMed:11940519, PubMed:28635961, PubMed:30296617). Has a major plasmalemmal distribution in a few specialized cells, such as in vestibular hair bundles and osteoblasts (By similarity) {ECO:0000250|UniProtKB:A1L3P4, ECO:0000269|PubMed:11940519, ECO:0000269|PubMed:28635961, ECO:0000269|PubMed:30296617} |
| Tissue Location | Ubiquitous. High expression in brain, skeletal muscle, and heart, but is also detected at lower levels in most other tissues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.
REFERENCES
Garbern, J.Y., et al. Brain 133 (PT 5), 1391-1402 (2010) :
Ohgaki, R., et al. Mol. Biol. Cell 21(7):1293-1304(2010)
Fukura, N., et al. J. Membr. Biol. 234(3):149-158(2010)
Fichou, Y., et al. Eur. J. Hum. Genet. 17(11):1378-1380(2009)
Roxrud, I., et al. Exp. Cell Res. 315(17):3014-3027(2009)
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