癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GPHB5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q86YW7 |
| Other Accession | NP_660154.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 14232 Da |
| Antigen Region | 62-91 aa |
| Gene ID | 122876 |
|---|---|
| Other Names | Glycoprotein hormone beta-5, Thyrostimulin subunit beta, GPHB5, GPB5, ZLUT1 |
| Target/Specificity | This GPHB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the C-terminal region of human GPHB5. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPHB5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPHB5 |
|---|---|
| Synonyms | GPB5, ZLUT1 |
| Function | Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. |
| Cellular Location | Secreted. |
| Tissue Location | Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).
REFERENCES
Suzuki, C., et al. Endocrinology 150(5):2237-2243(2009) Okajima, Y., et al. Regul. Pept. 148 (1-3), 62-67 (2008) : Okada, S.L., et al. Mol. Endocrinol. 20(2):414-425(2006) Sudo, S., et al. Endocrinology 146(8):3596-3604(2005) Heilig, R., et al. Nature 421(6923):601-607(2003)
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