癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMEM49 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q96GC9 |
| Other Accession | Q91ZQ0, Q99KU0, NP_112200.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46238 Da |
| Antigen Region | 377-406 aa |
| Gene ID | 81671 |
|---|---|
| Other Names | Vacuole membrane protein 1, Transmembrane protein 49, VMP1, TDC1, TMEM49 |
| Target/Specificity | This TMEM49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-406 amino acids of human TMEM49. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TMEM49 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VMP1 {ECO:0000303|PubMed:28890335, ECO:0000312|HGNC:HGNC:29559} |
|---|---|
| Function | Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:33850023, PubMed:33929485). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:33850023, PubMed:33929485). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:28890335, PubMed:30093494, PubMed:30933966, PubMed:33850023, PubMed:33929485). Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:31526472, PubMed:33850023). Modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). Plays an essential role in formation of cell junctions (PubMed:17724469). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (By similarity). Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity). |
| Cellular Location | Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Vacuole membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi- pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity).
REFERENCES
Pardo, R., et al. Pancreatology 10(1):19-26(2010)
Calvo-Garrido, J., et al. Mol. Biol. Cell 19(8):3442-3453(2008)
Fujita, S., et al. J. Mol. Biol. 378(3):492-504(2008)
Sauermann, M., et al. Oncogene 27(9):1320-1326(2008)
Ropolo, A., et al. J. Biol. Chem. 282(51):37124-37133(2007)
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