癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
XIRP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q702N8 |
| Other Accession | NP_919269.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 198561 Da |
| Antigen Region | 1338-1367 aa |
| Gene ID | 165904 |
|---|---|
| Other Names | Xin actin-binding repeat-containing protein 1, Cardiomyopathy-associated protein 1, XIRP1, CMYA1, XIN |
| Target/Specificity | This XIRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1338-1367 amino acids from the C-terminal region of human XIRP1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | XIRP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | XIRP1 (HGNC:14301) |
|---|---|
| Function | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). |
| Cellular Location | Cell junction, adherens junction. Cell junction, desmosome {ECO:0000250|UniProtKB:Q5PZ43}. Note=Colocalizes with actin stress fibers. |
| Tissue Location | Expressed in skeletal muscle at areas of Z-disk disruption in a longitudinal pattern spanning one or more sarcomeres (at protein level). [Isoform B]: Expressed in the heart (at protein level). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
XIRP1 protects actin filaments from depolymerization.
REFERENCES
Claeys, K.G., et al. Acta Neuropathol. 117(3):293-307(2009)
van der Ven, P.F., et al. Exp. Cell Res. 312(11):2154-2167(2006)
Pacholsky, D., et al. J. Cell. Sci. 117 (PT 22), 5257-5268 (2004) :
Sinn, H.W., et al. Dev. Dyn. 225(1):1-13(2002)
Wang, D.Z., et al. Development 126(6):1281-1294(1999)
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