癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
B4GALNT3 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q6L9W6 |
| Other Accession | NP_775864.3 |
| Reactivity | Human |
| Predicted | Rabbit, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 114975 Da |
| Antigen Region | 555-584 aa |
| Gene ID | 283358 |
|---|---|
| Other Names | Beta-1, 4-N-acetylgalactosaminyltransferase 3, B4GalNAcT3, Beta4GalNAc-T3, Beta4GalNAcT3, Beta-1, 4-N-acetylgalactosaminyltransferase III, N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2, NGalNAc-T2, B4GALNT3 |
| Target/Specificity | This B4GALNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 555-584 amino acids from the Central region of human B4GALNT3. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | B4GALNT3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | B4GALNT3 |
|---|---|
| Function | Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'- diacetyllactosediamine formation on gastric mucosa. |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Localizes to apical Golgi |
| Tissue Location | Highly expressed in testis, colon and stomach. Weakly expressed in other tissues. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM].
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Arking, D.E., et al. PLoS ONE 5 (3), E9879 (2010) :
Miller, E., et al. J. Biol. Chem. 283(4):1985-1991(2008)
Huang, J., et al. Mol. Cancer Res. 5(6):543-552(2007)
Ikehara, Y., et al. Glycobiology 16(9):777-785(2006)
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