癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PITPNM2 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BZ72 |
| Other Accession | NP_065896.1 |
| Reactivity | Human |
| Predicted | Mouse, Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 148933 Da |
| Antigen Region | 639-668 aa |
| Gene ID | 57605 |
|---|---|
| Other Names | Membrane-associated phosphatidylinositol transfer protein 2, Phosphatidylinositol transfer protein, membrane-associated 2, PITPnm 2, Pyk2 N-terminal domain-interacting receptor 3, NIR-3, PITPNM2, KIAA1457, NIR3 |
| Target/Specificity | This PITPNM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 639-668 amino acids from the Central region of human PITPNM2. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PITPNM2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PITPNM2 |
|---|---|
| Synonyms | KIAA1457, NIR3 |
| Function | Membrane-associated phosphatidylinositol (PI) transfer protein that shuttles PI between intracellular membranes and thereby maintains plasma membrane phosphoinositide signaling competence (PubMed:10022914, PubMed:25887399). Upon production of phosphatidic acid (PA), mediates the transfer of phosphatidylinositol from the endoplasmic reticulum to the plasma membrane at endoplasmic reticulum- plasma membrane contact sites. This transfer sustains phospholipase C (PLC)-coupled receptor signaling and replenishing of plasma membrane phosphoinositides following receptor-induced hydrolysis (PubMed:25887399). Promotes PIP2 replenishment following TCR stimulation; plays a critical role in T cell development by supporting calcium signaling in response to weak TCR stimulation during TCRbeta selection and positive selection of thymocytes, as well as maintaining peripheral T cell survival (By similarity). |
| Cellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Upon PIP2 hydrolysis, translocates to endoplasmic reticulum-plasma membrane contact sites |
| Tissue Location | Highly expressed in brain, heart, ovary, testis and thymus. Detected in small intestine, prostate, pancreas, skeletal muscle, liver, colon and placenta. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PITPNM2 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).
REFERENCES
Ocaka, L., et al. Cytogenet. Genome Res. 108(4):293-302(2005)
Tomsig, J.L., et al. J. Biol. Chem. 278(12):10048-10054(2003)
Lev, S., et al. Mol. Cell. Biol. 19(3):2278-2288(1999)
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