癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MMP28 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9H239 |
| Other Accession | NP_001027449.1, NP_077278.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58939 Da |
| Antigen Region | 195-223 aa |
| Gene ID | 79148 |
|---|---|
| Other Names | Matrix metalloproteinase-28, MMP-28, 3424-, Epilysin, MMP28, MMP25 |
| Target/Specificity | This MMP28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human MMP28. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MMP28 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MMP28 |
|---|---|
| Synonyms | MMP25 |
| Function | Can degrade casein. Could play a role in tissues homeostasis and repair. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is up- regulated in response to injury in the skin |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants encoding different isoforms have been described. [provided by RefSeq].
REFERENCES
Swingler, T.E., et al. Biochem. J. 427(3):391-400(2010)
Suomela, S., et al. Virchows Arch. 455(6):495-503(2009)
Rodgers, U.R., et al. Matrix Biol. 28(5):263-272(2009)
Heiskanen, T.J., et al. Matrix Biol. 28(2):74-83(2009)
Gruber, H.E., et al. Arthritis Res. Ther. 11 (6), R184 (2009) :
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