癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ARHGDIB Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P52566 |
| Other Accession | NP_001166.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22988 Da |
| Antigen Region | 160-188 aa |
| Gene ID | 397 |
|---|---|
| Other Names | Rho GDP-dissociation inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1 |
| Target/Specificity | This ARHGDIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the C-terminal region of human ARHGDIB. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARHGDIB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARHGDIB |
|---|---|
| Synonyms | GDIA2, GDID4, RAP1GN1 |
| Function | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Detected in bone marrow, thymus and spleen. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).
REFERENCES
Niu, H., et al. Oncol. Rep. 24(2):465-471(2010)
Zhen, H., et al. Int. J. Gynecol. Cancer 20(3):316-322(2010)
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Said, N., et al. Cancer Metastasis Rev. 28 (3-4), 327-333 (2009) :
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
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