癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CTAG2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O75638 |
| Other Accession | NP_758965.1, NP_066274.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21090 Da |
| Antigen Region | 122-149 aa |
| Gene ID | 30848 |
|---|---|
| Other Names | Cancer/testis antigen 2, CT2, Autoimmunogenic cancer/testis antigen NY-ESO-2, Cancer/testis antigen 62, CT62, L antigen family member 1, LAGE-1, CTAG2, ESO2, LAGE1 |
| Target/Specificity | This CTAG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-149 amino acids from the Central region of human CTAG2. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTAG2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTAG2 |
|---|---|
| Synonyms | ESO2, LAGE1 |
| Tissue Location | Testis and very low level in placenta and in some uterus samples. Observed in 25-50% of tumor samples of melanomas, non- small-cell lung carcinomas, bladder, prostate and head and neck cancers |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID 10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq].
REFERENCES
Wang, X.Y., et al. Oncol. Rep. 21(3):713-719(2009)
Shao, Y., et al. J. Cancer Res. Clin. Oncol. 134(4):495-502(2008)
Andrade, V.C., et al. Cancer Immun. 8, 2 (2008) :
Kan, T., et al. Oncology 70(1):25-33(2006)
Scanlan, M.J., et al. Immunol. Rev. 188, 22-32 (2002) :
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