癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NOSTRIN Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IVI9 |
| Other Accession | NP_443178.2, NP_001165103.1, NP_001034813.2 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57660 Da |
| Antigen Region | 296-325 aa |
| Gene ID | 115677 |
|---|---|
| Other Names | Nostrin, BM247 homolog, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, eNOS-trafficking inducer, NOSTRIN |
| Target/Specificity | This NOSTRIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human NOSTRIN. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NOSTRIN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NOSTRIN (HGNC:20203) |
|---|---|
| Function | Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. |
| Cellular Location | [Isoform 1]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344) |
| Tissue Location | Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.
REFERENCES
Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)
Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wiesenthal, A., et al. Traffic 10(1):26-34(2009)
Schilling, K., et al. Mol. Biol. Cell 17(9):3870-3880(2006)
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