癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DAO Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P14920 |
| Other Accession | NP_001908.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39474 Da |
| Antigen Region | 259-287 aa |
| Gene ID | 1610 |
|---|---|
| Other Names | D-amino-acid oxidase, DAAO, DAMOX, DAO, DAO, DAMOX |
| Target/Specificity | This DAO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-287 amino acids from the Central region of human DAO. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DAO Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DAO |
|---|---|
| Synonyms | DAMOX |
| Function | Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity (PubMed:16616139, PubMed:17088322, PubMed:17303072, PubMed:18544534, PubMed:20368421, PubMed:20567862, PubMed:20603179, PubMed:22203986, PubMed:23219954, PubMed:23391306, PubMed:25030849, PubMed:25701391, PubMed:29274788, PubMed:29326945, PubMed:30938755, PubMed:31799256, PubMed:32730563, PubMed:33484270, PubMed:34041270, PubMed:37558109, PubMed:38035964). Required to catabolize D-amino acids synthesized endogenously, of gastrointestinal bacterial origin or obtained from the diet, and to use these as nutrients (By similarity). Regulates the level of D-amino acid neurotransmitters in the brain, such as D-serine, a co-agonist of N- methyl D-aspartate (NMDA) receptors, and may modulate synaptic transmission (PubMed:17303072). Catalyzes the first step of the racemization of D-DOPA to L-DOPA, for possible use in an alternative dopamine biosynthesis pathway (PubMed:17303072). Also catalyzes the first step of the chiral inversion of N(gamma)-nitro-D-arginine methyl ester (D-NNA) to its L-enantiomer L-NNA that acts as a nitric oxide synthase inhibitor (By similarity). The hydrogen peroxide produced in the reaction provides protection against microbial infection; it contributes to the oxidative killing activity of phagocytic leukocytes and protects against bacterial colonization of the small intestine (By similarity). Enzyme secreted into the lumen of the intestine may not be catalytically active and could instead be proteolytically cleaved into peptides with antimicrobial activity (By similarity). The hydrogen peroxide produced in the reaction may also play a role in promoting cellular senescence in response to DNA damage (PubMed:30659069). Could act as a detoxifying agent which removes D-amino acids accumulated during aging (PubMed:17303072). |
| Cellular Location | Peroxisome matrix. Cytoplasm, cytosol. Presynaptic active zone {ECO:0000250|UniProtKB:O35078}. Secreted Note=Transiently present in the cytosol before being delivered to the peroxisomes (PubMed:21679769, PubMed:31799256). In the cerebellum, a fraction of protein localizes to the presynaptic active zone, where its activity is regulated by protein BSN (By similarity). Secreted into the lumen of the small intestine (PubMed:27670111) {ECO:0000250|UniProtKB:O35078, ECO:0000269|PubMed:21679769, ECO:0000269|PubMed:27670111, ECO:0000269|PubMed:31799256} |
| Tissue Location | Expressed in the cerebellum, in astrocytes of the cortex, in motor neurons and fibers of the lumbar spinal cord (at protein level) (PubMed:17880399, PubMed:18544534, PubMed:18560437, PubMed:24138986, PubMed:34041270). Expressed in goblet cells of the small intestine (at protein level) (PubMed:27670111). Increased in the cerebellum of schizophrenic patients (at protein level) (PubMed:17880399, PubMed:18560437). Decreased in motor neurons of the spinal cord of patients with amyotrophic lateral sclerosis (at protein level) (PubMed:24138986). Expressed in the cerebellum, spinal cord, kidney, and thalamus (PubMed:17880399). Abundant in glia of the cerebellum and predominantly neuronal in the dorsolateral prefrontal cortex, hippocampus and substantia nigra (PubMed:17880399) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.
REFERENCES
Kim, B., et al. Psychiatry Res 179(2):121-125(2010)
Caldinelli, L., et al. Protein Sci. 19(8):1500-1512(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Ohnuma, T., et al. Schizophr. Res. 118 (1-3), 300-302 (2010) :
Mitchell, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7556-7561(2010)
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