癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PDCD4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | Q53EL6 |
| Other Accession | Q9JID1, Q61823, NP_055271.2, NP_663314.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51735 Da |
| Antigen Region | 121-149 aa |
| Gene ID | 27250 |
|---|---|
| Other Names | Programmed cell death protein 4, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a, PDCD4, H731 |
| Target/Specificity | This PDCD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-149 amino acids from the Central region of human PDCD4. |
| Dilution | IHC-P-Leica~~1:500 WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDCD4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDCD4 |
|---|---|
| Synonyms | H731 |
| Function | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q61823}. Cytoplasm {ECO:0000250|UniProtKB:Q61823}. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133) |
| Tissue Location | Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.
REFERENCES
Hayashi, A., et al. Hum. Pathol. 41(11):1507-1515(2010)
Zhang, X., et al. Cancer Sci. 101(10):2163-2170(2010)
Wang, W., et al. Exp. Cell Res. 316(15):2456-2464(2010)
Santhanam, A.N., et al. Oncogene 29(27):3921-3932(2010)
Fassan, M., et al. Oncol. Rep. 24(1):135-139(2010)
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