癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC38A5 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WUX1 |
| Other Accession | NP_277053.2 |
| Reactivity | Human |
| Predicted | Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51457 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 92745 |
|---|---|
| Other Names | Sodium-coupled neutral amino acid transporter 5, Solute carrier family 38 member 5, System N transporter 2, SLC38A5, JM24, SN2, SNAT5 |
| Target/Specificity | This SLC38A5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC38A5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC38A5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC38A5 |
|---|---|
| Synonyms | JM24, SN2 {ECO:0000303|PubMed:11243884}, |
| Function | Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11243884). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate- glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant (PubMed:11243884). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:A2VCW5}; Multi-pass membrane protein. Note=Localized at astroglial membrane. {ECO:0000250|UniProtKB:A2VCW5} |
| Tissue Location | Predominantly expressed in stomach, brain, liver, lung and intestinal tract. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a system N sodium-coupled amino acid transporter involved in the transfer of glutamine, asparagine, histidine, serine, alanine, and glycine. The encoded protein does not transport charged amino acids, imino acids, or N-alkylated amino acids. This transporter is not inhibited by lithium.
REFERENCES
Broer, S. Physiol. Rev. 88(1):249-286(2008)
Froyen, G., et al. Hum. Genet. 121(5):539-547(2007)
Nakanishi, T., et al. Biochem. Biophys. Res. Commun. 281(5):1343-1348(2001)
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