癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Pxk Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8BX57 |
| Other Accession | Q4FZZ1, Q7Z7A4, NP_663433.2, NP_840063.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 65231 Da |
| Antigen Region | 164-193 aa |
| Gene ID | 218699 |
|---|---|
| Other Names | PX domain-containing protein kinase-like protein, Modulator of Na, K-ATPase, MONaKA, Pxk {ECO:0000312|MGI:MGI:1289230} |
| Target/Specificity | This Mouse Pxk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-193 amino acids from the Central region of mouse Pxk. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Pxk Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Pxk {ECO:0000312|MGI:MGI:1289230} |
|---|---|
| Function | Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma membrane |
| Tissue Location | Isoform 1 is present in all tissues examined. Isoform 2 is found in all tissues except skeletal muscle and very low levels in spleen. Both isoforms are widely expressed throughout the nervous system however levels of isoform 2 are higher in purified hippocampal and cortical neurons whereas glial cells express more isoform 1 than isoform 2. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Pxk binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.
REFERENCES
Mao, H., et al. J. Neurosci. 25(35):7934-7943(2005)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
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