癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Scyl2 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q8CFE4 |
| Other Accession | NP_932138.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 103317 Da |
| Antigen Region | 585-613 aa |
| Gene ID | 213326 |
|---|---|
| Other Names | SCY1-like protein 2, Coated vesicle-associated kinase of 104 kDa, Scyl2, Cvak104, D10Ertd802e |
| Target/Specificity | This Mouse Scyl2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 585-613 amino acids from the Central region of mouse Scyl2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Scyl2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Scyl2 {ECO:0000312|MGI:MGI:1289172} |
|---|---|
| Function | Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (By similarity). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (PubMed:26203146). |
| Cellular Location | Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q6P3W7}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q6P3W7}. Endosome membrane {ECO:0000250|UniProtKB:Q6P3W7}. Note=Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes {ECO:0000250|UniProtKB:Q6P3W7} |
| Tissue Location | Ubiquitously expressed. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. Scyl2 may be a serine/threonine-protein kinase. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (By similarity).
REFERENCES
Duwel, M., et al. Mol. Biol. Cell 17(10):4513-4525(2006)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
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