癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CNNM2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q9H8M5 |
| Other Accession | NP_951058.1, NP_060119.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 96623 Da |
| Antigen Region | 646-674 aa |
| Gene ID | 54805 |
|---|---|
| Other Names | Metal transporter CNNM2, Ancient conserved domain-containing protein 2, Cyclin-M2, CNNM2, ACDP2 |
| Target/Specificity | This CNNM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 646-674 amino acids from the C-terminal region of human CNNM2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CNNM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNNM2 |
|---|---|
| Synonyms | ACDP2 |
| Function | Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CNNM2 is a divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)
Yasuno, K., et al. Nat. Genet. 42(5):420-425(2010)
Simon-Sanchez, J., et al. Nat. Genet. 41(12):1308-1312(2009)
Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009)
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