癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
COL2A1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| IHC-P, E |
|---|---|
| Primary Accession | P02458 |
| Other Accession | Q91717, P05539, P28481, P02459, P02454, P11087, P02452, P02457, P02453 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Mouse, Rat, Chicken, Xenopus, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 141785 Da |
| Antigen Region | 469-497 aa |
| Gene ID | 1280 |
|---|---|
| Other Names | Collagen alpha-1(II) chain, Alpha-1 type II collagen, Collagen alpha-1(II) chain, Chondrocalcin, COL2A1 |
| Target/Specificity | This COL2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 469-497 amino acids from the N-terminal region of human COL2A1. |
| Dilution | IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | COL2A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COL2A1 (HGNC:2200) |
|---|---|
| Function | Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. |
| Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793} |
| Tissue Location | Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Alpha-1 chain of type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutant forms of this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
REFERENCES
Olavarrieta,L., Clin. Genet. 73 (3), 262-267 (2008)
McAlinden,A., Hum. Mutat. 29 (1), 83-90 (2008)
Forzano,F., Am. J. Med. Genet. A 143 (23), 2815-2820 (2007)
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