癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MAS1 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P04201 |
| Other Accession | NP_002368.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37465 Da |
| Antigen Region | 285-314 aa |
| Gene ID | 4142 |
|---|---|
| Other Names | Proto-oncogene Mas, MAS1, MAS |
| Target/Specificity | This MAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the C-terminal region of human MAS1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAS1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MAS1 |
|---|---|
| Synonyms | MAS |
| Function | G protein-coupled receptor that plays key roles in the renin- angiotensin system (RAS) specifically in the protective, counter- regulatory arm of the RAS (PubMed:25967876). Receptor mainly stimulated by angiotensin 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2 (PubMed:17984366). Activation promotes nitric oxide via PI3K/Akt-eNOS pathway (PubMed:17984366). Modulates also the MAPK, ERK1/2, and NF-kappa-B signaling (PubMed:25967876). Positive regulation of AGTR1 levels occurs through activation of the G proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade (PubMed:15809376, PubMed:16611642). The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (PubMed:15809376, PubMed:16611642). Acts as functional receptor for CXCL17 and induces chemotactic movement (PubMed:41167449). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.
REFERENCES
Yang, J.K., et al. Diabetes Care 33(10):2271-2273(2010)
Reis, A.B., et al. J. Mol. Histol. 41(1):75-80(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Iwai, M., et al. Hypertens. Res. 32(7):533-536(2009)
Vaz-Silva, J., et al. Reprod Sci 16(3):247-256(2009)
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