癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse TRPV3 Antibody (N-term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8K424 |
| Reactivity | Mouse |
| Predicted | Rat, Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 90663 Da |
| Antigen Region | 90-119 aa |
| Gene ID | 246788 |
|---|---|
| Other Names | Transient receptor potential cation channel subfamily V member 3, TrpV3, Trpv3 |
| Target/Specificity | This Mouse TRPV3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the N-terminal region of mouse TRPV3. |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse TRPV3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Trpv3 |
|---|---|
| Function | Non-selective calcium permeant cation channel (PubMed:12016205). It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius (By similarity). Activation exhibits an outward rectification (By similarity). The channel pore can dilate to provide permeability to larger cations (By similarity). May associate with TRPV1 and may modulate its activity (By similarity). Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8NET8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NET8}. Cytoplasm {ECO:0000250|UniProtKB:Q8NET8}. Lysosome {ECO:0000250|UniProtKB:Q8NET8}. Note=Targeted to lysosome for degradation in a SNX11-dependent manner {ECO:0000250|UniProtKB:Q8NET8} |
| Tissue Location | Expressed in keratinocytes and hair follicles. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TRPV3 belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels.
REFERENCES
Frederick,J., Biochem. Biophys. Res. Commun. 358 (4), 1058-1064 (2007)
Asakawa,M., J. Invest. Dermatol. 126 (12), 2664-2672 (2006)
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