癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SEMG1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P04279 |
| Other Accession | NP_002998.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52131 Da |
| Antigen Region | 92-121 aa |
| Gene ID | 6406 |
|---|---|
| Other Names | Semenogelin-1, Semenogelin I, SGI, Alpha-inhibin-92, Alpha-inhibin-31, Seminal basic protein, SEMG1, SEMG |
| Target/Specificity | This SEMG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-121 amino acids from the N-terminal region of human SEMG1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEMG1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEMG1 |
|---|---|
| Synonyms | SEMG |
| Function | Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. |
| Cellular Location | Secreted. |
| Tissue Location | Seminal vesicle. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely.
REFERENCES
Mitra, A., et al. Biol. Reprod. 82(3):489-496(2010)
Yoshida, K., et al. Cell Motil. Cytoskeleton 66(2):99-108(2009)
Ahmed, S.U., et al. Cytotherapy 11(2):238-244(2009)
Edstrom, A.M., et al. J. Immunol. 181(5):3413-3421(2008)
Emami, N., et al. J. Biol. Chem. 283(28):19561-19569(2008)
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