癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PGF Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P49763 |
| Other Accession | NP_002623.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24789 Da |
| Antigen Region | 120-148 aa |
| Gene ID | 5228 |
|---|---|
| Other Names | Placenta growth factor, PlGF, PGF, PGFL, PLGF |
| Target/Specificity | This PGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-148 amino acids from the Central region of human PGF. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PGF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PGF |
|---|---|
| Synonyms | PGFL, PLGF |
| Function | Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. |
| Cellular Location | Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin |
| Tissue Location | While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The PGF gene encodes placenta growth factor, a homolog of vascular endothelial growth factor (VEGFA; MIM 192240), that selectively binds to VEGFR1 (FLT1; MIM 165070) and is involved in angiogenesis (Fischer et al., 2007 [PubMed 17981115]; Bais et al., 2010 [PubMed 20371352]).
REFERENCES
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Cowans, N.J., et al. Prenat. Diagn. 30(6):565-570(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
Andersson, M.K., et al. BMC Cancer 10, 249 (2010) :
Pan, P., et al. BMC Cell Biol. 11, 36 (2010) :
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