癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PLCD3 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q8N3E9 |
| Other Accession | Q8K2J0, NP_588614.1 |
| Reactivity | Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 89258 Da |
| Antigen Region | 60-89 aa |
| Gene ID | 113026 |
|---|---|
| Other Names | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-3, Phosphoinositide phospholipase C-delta-3, Phospholipase C-delta-3, PLC-delta-3, PLCD3, KIAA1964 |
| Target/Specificity | This PLCD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human PLCD3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLCD3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PLCD3 (HGNC:9061) |
|---|---|
| Synonyms | KIAA1964 |
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). |
| Cellular Location | Cell membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis (PubMed:17041247). The membrane binding is driven by the C2 domain and involves non-specific electrostatic interactions between the calcium-induced cationic surface of protein and the anionic membrane and specific interactions involving calcium and phosphatidylserine (PS) (PubMed:11706040). The PS selectivity governs its specific calcium-dependent subcellular targeting to the plasma membrane (PubMed:11706040). |
| Tissue Location | Present in corneal epithelial cells (at protein level). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq].
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Segat, L., et al. Vaccine 28(10):2201-2206(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009)
Rebecchi, M.J., et al. Adv. Enzyme Regul. 49(1):59-73(2009)
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