癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMPRSS13 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BYE2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 63167 Da |
| Antigen Region | 431-460 aa |
| Gene ID | 84000 |
|---|---|
| Other Names | Transmembrane protease serine 13, 3421-, Membrane-type mosaic serine protease, Mosaic serine protease, TMPRSS13, MSP, TMPRSS11 |
| Target/Specificity | This TMPRSS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 431-460 amino acids from the C-terminal region of human TMPRSS13. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TMPRSS13 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMPRSS13 |
|---|---|
| Synonyms | MSP, TMPRSS11 |
| Function | Serine protease (PubMed:20977675, PubMed:28710277, PubMed:34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed:34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed:20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Secreted. Cytoplasm Note=The non-phosphorylated, inactive full length protein localizes intracellularly (PubMed:28710277). N-glycosylation and phosphorylation is required for trafficking to the cell surface (PubMed:28710277, PubMed:34562451, PubMed:35796294). Interaction with SPINT1/HAI-1 and SPINT2/HAI-2 facilitate its translocation to the cell surface (PubMed:34562451, PubMed:35796294). Proteolytic cleavage is required for secretion (PubMed:35796294). |
| Tissue Location | Expressed in placenta. [Isoform 3]: Expressed in lung, placenta, pancreas, and prostate (PubMed:11267681). Weakly expressed in testis and peripheral blood lymphocytes (PubMed:11267681) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TMPRSS13 is a cell membrane serine protease. It is a member of a larger family of membrane attached serine proteases, a poorly defined group that includes TMPRSS11A, B, C, D, E, F, Hepsin, Corin, Matriptase 1, 2 and 3. TMPRSS13 has a domain structure of an aminoterminal cytoplasmic domain, which is much longer than the other TMPRSS family members, followed by a transmembrane domain, an SRCR domain (Scavenger receptor cysteine rich), an LDL receptor like domain, another SRCR domain, followed by the trypsin like serine protease domain. The cytoplasmic domain contains a number of tandem repeat elements, the function of which is not clear, but which may play a regulatory role.
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