癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LSM14A Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8ND56 |
| Other Accession | Q8K2F8, Q3MHF8, NP_001107565.1, NP_056393.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50530 Da |
| Antigen Region | 311-340 aa |
| Gene ID | 26065 |
|---|---|
| Other Names | Protein LSM14 homolog A, Protein FAM61A, Protein SCD6 homolog, Putative alpha-synuclein-binding protein, AlphaSNBP, RNA-associated protein 55A, hRAP55, hRAP55A, LSM14A, C19orf13, FAM61A, RAP55, RAP55A |
| Target/Specificity | This LSM14A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-340 amino acids from the C-terminal region of human LSM14A. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LSM14A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LSM14A {ECO:0000303|PubMed:26339800, ECO:0000312|HGNC:HGNC:24489} |
|---|---|
| Function | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). |
| Cellular Location | Cytoplasm, P-body. Cytoplasm, cytoskeleton, spindle. Cytoplasm, Stress granule |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.
REFERENCES
Marnef, A., et al. Int. J. Biochem. Cell Biol. 41(5):977-981(2009)
Tanaka, K.J., et al. J. Biol. Chem. 281(52):40096-40106(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Yang, W.H., et al. RNA 12(4):547-554(2006)
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