癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SEPT5 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q99719 |
| Other Accession | Q9JJM9, Q9Z2Q6, NP_002679.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42777 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 5413 |
|---|---|
| Other Names | Septin-5, Cell division control-related protein 1, CDCrel-1, Peanut-like protein 1, SEPT5, PNUTL1 |
| Target/Specificity | This SEPT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SEPT5. |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEPT5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEPTIN5 (HGNC:9164) |
|---|---|
| Synonyms | PNUTL1, SEPT5 |
| Function | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha- granules |
| Tissue Location | Expressed at high levels in the CNS, as well as in heart and platelets (at protein level). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq].
REFERENCES
Jung, A.E., et al. Mol. Ther. 16(6):1048-1055(2008)
Amin, N.D., et al. J. Neurosci. 28(14):3631-3643(2008)
Xin, X., et al. J. Histochem. Cytochem. 55(11):1089-1094(2007)
Blaser, S., et al. J. Pathol. 210(1):103-110(2006)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
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