癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MXI1 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P50539 |
| Other Accession | O09015, P50540, NP_005953.4, NP_569157.2, NP_001008541.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26062 Da |
| Antigen Region | 53-82 aa |
| Gene ID | 4601 |
|---|---|
| Other Names | Max-interacting protein 1, Max interactor 1, Class C basic helix-loop-helix protein 11, bHLHc11, MXI1, BHLHC11 |
| Target/Specificity | This MXI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the Central region of human MXI1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MXI1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MXI1 |
|---|---|
| Synonyms | BHLHC11 |
| Function | Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. |
| Cellular Location | Nucleus. |
| Tissue Location | High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
REFERENCES
Lofstedt, T., et al. Exp. Cell Res. 315(11):1924-1936(2009)
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
Tsao, C.C., et al. Cancer Biol. Ther. 7(10):1619-1627(2008)
Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28(11):745-749(2007)
Dugast-Darzacq, C., et al. FEBS J. 274(17):4643-4653(2007)
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