癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KIF16b Antibody 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96L93 |
| Other Accession | B1AVY7, NP_078980.3 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 152011 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 55614 |
|---|---|
| Other Names | Kinesin-like protein KIF16B, Sorting nexin-23, KIF16B, C20orf23, KIAA1590, SNX23 |
| Target/Specificity | This KIF16b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human KIF16b. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KIF16b Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KIF16B |
|---|---|
| Synonyms | C20orf23, KIAA1590, SNX23 |
| Function | Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. |
| Cellular Location | Cytoplasm, cytoskeleton. Early endosome membrane. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14 |
| Tissue Location | Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
KIF16b may be involved in several stages of intracellular trafficking. Probable microtubule-dependent motor protein (By similarity).
REFERENCES
Vasilescu, J., et al. J. Proteome Res. 6(1):298-305(2007)
Seet, L.F., et al. Biochim. Biophys. Acta 1761(8):878-896(2006)
Miki, H., et al. Trends Cell Biol. 15(9):467-476(2005)
Hoepfner, S., et al. Cell 121(3):437-450(2005)
Worby, C.A., et al. Nat. Rev. Mol. Cell Biol. 3(12):919-931(2002)
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