DKK3 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| IHC-P, WB, E |
---|---|
Primary Accession | Q9UBP4 |
Other Accession | NP_037385 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 38390 Da |
Antigen Region | 15-45 aa |
Gene ID | 27122 |
---|---|
Other Names | Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3, DKK3, REIC |
Target/Specificity | This DKK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human DKK3. |
Dilution | IHC-P~~1:100~500 WB~~1:1000 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DKK3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DKK3 |
---|---|
Synonyms | REIC |
Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). |
Cellular Location | Secreted. |
Tissue Location | Highest expression in heart, brain, and spinal cord. {ECO:0000269|PubMed:10570958, ECO:0000269|Ref.4} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.

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