癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZFPM2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q8WW38 |
| Other Accession | NP_036214.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 128159 Da |
| Antigen Region | 883-911 aa |
| Gene ID | 23414 |
|---|---|
| Other Names | Zinc finger protein ZFPM2, Friend of GATA protein 2, FOG-2, Friend of GATA 2, hFOG-2, Zinc finger protein 89B, Zinc finger protein multitype 2, ZFPM2, FOG2, ZNF89B |
| Target/Specificity | This ZFPM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 883-911 amino acids from the C-terminal region of human ZFPM2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZFPM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZFPM2 |
|---|---|
| Synonyms | FOG2, ZNF89B |
| Function | Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed at low level. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq].
REFERENCES
De Luca, A., et al. Clin. Genet. (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Hyun, S., et al. Cell 139(6):1096-1108(2009)
Rouf, R., et al. Circ. Res. 103(5):493-501(2008)
Bleyl, S.B., et al. Eur. J. Hum. Genet. 15(9):950-958(2007)
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