癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LIM2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P55344 |
| Other Accession | P54825, P56563, P20274, NP_085915.2, NP_001155220.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 19674 Da |
| Antigen Region | 110-137 aa |
| Gene ID | 3982 |
|---|---|
| Other Names | Lens fiber membrane intrinsic protein, MP18, MP19, MP20, LIM2 |
| Target/Specificity | This LIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-137 amino acids from the C-terminal region of human LIM2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LIM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LIM2 |
|---|---|
| Function | Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Eye lens specific.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
LIM2 is an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation.
REFERENCES
Ponnam, S.P., et al. Mol. Vis. 14, 1204-1208 (2008) :
Hsu, H., et al. Sheng Wu Gong Cheng Xue Bao 20(4):507-515(2004)
Wistow, G., et al. Mol. Vis. 8, 171-184 (2002) :
Wistow, G., et al. Mol. Vis. 8, 185-195 (2002) :
Pras, E., et al. Am. J. Hum. Genet. 70(5):1363-1367(2002)
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