癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TRAPPC2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P0DI81 |
| Other Accession | F1SRI0, Q9CQP2, Q08CN0, Q5ZKP4, Q3T0F2, P0DI82 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Zebrafish, Mouse, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 16445 Da |
| Antigen Region | 11-39 aa |
| Gene ID | 6399 |
|---|---|
| Other Names | Trafficking protein particle complex subunit 2, Sedlin, TRAPPC2, SEDL |
| Target/Specificity | This TRAPPC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human TRAPPC2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRAPPC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRAPPC2 |
|---|---|
| Synonyms | SEDL |
| Function | Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi. |
| Cellular Location | Cytoplasm, perinuclear region. Endoplasmic reticulum-Golgi intermediate compartment. Nucleus. Cytoplasm. Note=Localized in perinuclear granular structures. |
| Tissue Location | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TRAPPC2 is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y.
REFERENCES
Liu, X., et al. J. Cell. Biochem. 109(6):1129-1133(2010)
Jeyabalan, J., et al. PLoS ONE 5 (5), E10646 (2010) :
Xia, X.Y., et al. Clin. Chim. Acta 410 (1-2), 39-42 (2009) :
Guo, H., et al. J. Genet. 88(1):87-91(2009)
Xiong, F., et al. Eur. J. Hum. Genet. 17(4):510-516(2009)
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