癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NAT5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P61599 |
| Other Accession | Q7ZXR3, P61600, Q2PFM2, Q58ED9, NP_852669.1, NP_852668.1, NP_057184.1 |
| Reactivity | Human |
| Predicted | Zebrafish, Monkey, Mouse, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20368 Da |
| Antigen Region | 127-155 aa |
| Gene ID | 51126 |
|---|---|
| Other Names | N-alpha-acetyltransferase 20, Methionine N-acetyltransferase, N-acetyltransferase 5, N-terminal acetyltransferase B complex catalytic subunit NAA20, N-terminal acetyltransferase B complex catalytic subunit NAT5, NatB complex subunit NAT5, NatB catalytic subunit, NAA20, NAT5 |
| Target/Specificity | This NAT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the C-terminal region of human NAT5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NAT5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NAA20 |
|---|---|
| Synonyms | NAT5 |
| Function | Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln (PubMed:34230638). Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. |
| Cellular Location | Cytoplasm. Nucleus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM].
REFERENCES
Kuo, H.P., et al. Sci Signal 3 (108), RA9 (2010) :
Evjenth, R., et al. J. Biol. Chem. 284(45):31122-31129(2009)
Polevoda, B., et al. BMC Proc 3 SUPPL 6, S2 (2009) :
Starheim, K.K., et al. Biochem. J. 415(2):325-331(2008)
Sanchez-Puig, N., et al. Protein Sci. 15(8):1968-1976(2006)
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