癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GPR87 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BY21 |
| Other Accession | Q99MT7, NP_076404.3 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41436 Da |
| Antigen Region | 329-357 aa |
| Gene ID | 53836 |
|---|---|
| Other Names | G-protein coupled receptor 87, G-protein coupled receptor 95, GPR87, GPR95 |
| Target/Specificity | This GPR87 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-357 amino acids from the C-terminal region of human GPR87. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR87 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR87 |
|---|---|
| Synonyms | GPR95 |
| Function | Receptor for lysophosphatidic acid (LPA) (PubMed:17905198). Necessary for p53/TP53-dependent survival in response to DNA damage (PubMed:19602589). Promotes the Hippo-YAP signaling pathway and thereby modulates glycolysis and oxidative stress production by the regulation of hexokinase-2/HK2 (PubMed:35843477). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
G protein-coupled receptors play a role in cell communication. They are characterized by an extracellular N terminus, 7 transmembrane regions, and an intracellular C terminus.
REFERENCES
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Zhang, Y., et al. Cancer Res. 69(15):6049-6056(2009)
Glatt, S., et al. Int. J. Cancer 122(9):2008-2016(2008)
Gugger, M., et al. Dis. Markers 24(1):41-50(2008)
Tabata, K., et al. Biochem. Biophys. Res. Commun. 363(3):861-866(2007)
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