癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CREB3L4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8TEY5 |
| Other Accession | NP_570968.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43432 Da |
| Antigen Region | 338-366 aa |
| Gene ID | 148327 |
|---|---|
| Other Names | Cyclic AMP-responsive element-binding protein 3-like protein 4, cAMP-responsive element-binding protein 3-like protein 4, Androgen-induced basic leucine zipper protein, AIbZIP, Attaching to CRE-like 1, ATCE1, Cyclic AMP-responsive element-binding protein 4, CREB-4, cAMP-responsive element-binding protein 4, Transcript induced in spermiogenesis protein 40, Tisp40, hJAL, Processed cyclic AMP-responsive element-binding protein 3-like protein 4, CREB3L4, AIBZIP, CREB4, JAL |
| Target/Specificity | This CREB3L4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 338-366 amino acids from the C-terminal region of human CREB3L4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CREB3L4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CREB3L4 |
|---|---|
| Synonyms | AIBZIP, CREB4, JAL |
| Function | Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single- pass type II membrane protein. Note=May also be located in Golgi apparatus |
| Tissue Location | According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines Expressed in prostatic luminal epithelial cells (at protein level) Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
cAMP response element-binding (CREB) proteins are a family of mammalian transcription activators. For further background information on CREB proteins, see CREB1 (MIM 123810).[supplied by OMIM].
REFERENCES
Ben Aicha, S., et al. Physiol. Genomics 31(2):295-305(2007)
Stirling, J., et al. Mol. Biol. Cell 17(1):413-426(2006)
Stelzer, G., et al. Endocrinology 143(5):1578-1588(2002)
Qi, H., et al. Cancer Res. 62(3):721-733(2002)
Cao, G., et al. J. Hum. Genet. 47(7):373-376(2002)
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