癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GPX8 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8TED1 |
| Other Accession | NP_001008398.2 |
| Reactivity | Human |
| Predicted | Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 23881 Da |
| Antigen Region | 164-193 aa |
| Gene ID | 493869 |
|---|---|
| Other Names | Probable glutathione peroxidase 8, GPx-8, GSHPx-8, GPX8 |
| Target/Specificity | This GPX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-193 amino acids from the C-terminal region of human GPX8. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPX8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GPX8 |
|---|---|
| Function | Acts as an endoplasmic reticulum (ER) thiol peroxidase that maintains ER redox homeostasis and protects the cytosol from ER-derived H(2)O(2)(PubMed:24566470, PubMed:32719007). Functions in a redox relay with ERO1A, using ERO1A-generated H(2)O(2) to drive PDI oxidation, linking peroxide detoxification to productive disulfide formation (PubMed:21215271). Modulates endoplasmic reticulum Ca(2+) levels mainly through SERCA pump activity and partially by influencing passive Ca(2+) leakage (PubMed:28129698). |
| Cellular Location | Endoplasmic reticulum membrane. Note=Also enriched in mitochondria- associated membranes (MAM). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GPX8 belongs to the glutathione peroxidase family. Glutathione peroxidase is an enzyme whose principal function is to protect against damage from endogenously-formed hydroxyperoxides, catalysing the reduction of hydroxyperoxides by glutathione. Several forms of the enzyme are known. It has a catalytic activity of 2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
REFERENCES
Toppo, S., et al. Antioxid. Redox Signal. 10(9):1501-1514(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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