癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TRPC1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P48995 |
| Other Accession | Q9TUN9, Q61056, O18784, NP_003295.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 91212 Da |
| Antigen Region | 765-793 aa |
| Gene ID | 7220 |
|---|---|
| Other Names | Short transient receptor potential channel 1, TrpC1, Transient receptor protein 1, TRP-1, TRPC1, TRP1 |
| Target/Specificity | This TRPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 765-793 amino acids from the C-terminal region of human TRPC1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRPC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRPC1 |
|---|---|
| Synonyms | TRP1 |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11139478, PubMed:15016832, PubMed:39478185). Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Seems to be ubiquitous. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TRPC1 belongs to the transient receptor potential (TRP) superfamily of cation channels. TRP cation channels are involved in diverse physiologic processes, including receptor- and store-operated Ca(2+) entry, mineral absorption, and cell death. They also function as sensors for pain, heat, cold, sound, stretch, and osmotic changes (Zhang et al., 2009 [PubMed 19193631]).
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Bomben, V.C., et al. Glia 58(10):1145-1156(2010)
Lu, M., et al. J. Mol. Endocrinol. 44(5):285-294(2010)
Gonzalez-Cobos, J.C., et al. Front. Biosci. 15, 1023-1039 (2010) :
Ingueneau, C., et al. J. Cell. Mol. Med. 13 (8B), 1620-1631 (2009) :
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