癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RIMBP3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q9UFD9 |
| Other Accession | A6NJZ7, A6NNM3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 180717 Da |
| Antigen Region | 180-209 aa |
| Gene ID | 85376 |
|---|---|
| Other Names | RIMS-binding protein 3A, RIM-BP3A, RIMS-binding protein 31, RIM-BP31, RIMBP3, KIAA1666, RIMBP3A |
| Target/Specificity | This RIMBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-209 amino acids from the N-terminal region of human RIMBP3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RIMBP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RIMBP3 |
|---|---|
| Synonyms | KIAA1666, RIMBP3A |
| Function | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3V0F0}. Note=In elongating spermatids, localizes to the manchette. {ECO:0000250|UniProtKB:Q3V0F0} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
RIM-binding proteins (RIMBPs) serve as adaptors during vesicle fusion and release by forming links between synaptic-vesicle fusion apparatuses and calcium channels. RIMBP3 has been identified as a novel manchette-associated protein, and three members of RIMBP3 are known to exist: RIMBP3A, RIMBP3B and RIMBP3C. Each form of RIMBP3 exists as a large multidomain protein encoding three SH3-domains and two to three fibronectin III repeats. RIMBP3 plays a role in spermatid development and is required for normal sperm morphology and male fertility. RIMBP3 is found at high levels outside of the nervous system, with especially high expression in testis. RIMBP3C (RIMS binding protein 3C), also known as RIMBP3.3, or RIM-BP3.3, is a 1545 amino acid protein.
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