癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PAX2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q02962 |
| Other Accession | NP_003978.2, NP_000269.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44706 Da |
| Antigen Region | 187-216 aa |
| Gene ID | 5076 |
|---|---|
| Other Names | Paired box protein Pax-2, PAX2 |
| Target/Specificity | This PAX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of human PAX2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PAX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAX2 |
|---|---|
| Function | Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
REFERENCES
Monte, N.M., et al. Cancer Res. 70(15):6225-6232(2010)
Ozcan, A., et al. Arch. Pathol. Lab. Med. 134(8):1121-1129(2010)
Quick, C.M., et al. Hum. Pathol. 41(8):1145-1149(2010)
Martinovic-Bouriel, J., et al. Am. J. Med. Genet. A 152A (4), 830-835 (2010) :
Rabban, J.T., et al. Am. J. Surg. Pathol. 34(2):137-146(2010)
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