癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CRLF1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O75462 |
| Other Accession | Q9JM58, NP_004741.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46302 Da |
| Antigen Region | 255-283 aa |
| Gene ID | 9244 |
|---|---|
| Other Names | Cytokine receptor-like factor 1, Cytokine-like factor 1, CLF-1, ZcytoR5, CRLF1 |
| Target/Specificity | This CRLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-283 amino acids from the Central region of human CRLF1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CRLF1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRLF1 |
|---|---|
| Function | In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system. |
| Cellular Location | Secreted. |
| Tissue Location | Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq].
REFERENCES
Tsuritani, K., et al. Calcif. Tissue Int. 86(1):47-57(2010)
Crisponi, L., et al. Am. J. Hum. Genet. 80(5):971-981(2007)
Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Heese, K., et al. J. Cell. Biochem. 91(5):1030-1042(2004)
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