癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ANXA9 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O76027 |
| Other Accession | NP_003559.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38364 Da |
| Antigen Region | 208-235 aa |
| Gene ID | 8416 |
|---|---|
| Other Names | Annexin A9, Annexin XXXI, Annexin-31, Annexin-9, Pemphaxin, ANXA9, ANX31 |
| Target/Specificity | This ANXA9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-235 amino acids from the Central region of human ANXA9. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ANXA9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ANXA9 (HGNC:547) |
|---|---|
| Function | Plays a role in epidermal differentiation (PubMed:10899159). Can bind acetylcholine (PubMed:10899159). |
| Cellular Location | Lateral cell membrane {ECO:0000250|UniProtKB:Q9JHQ0} |
| Tissue Location | Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.
REFERENCES
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Goebeler, V., et al. FEBS Lett. 546 (2-3), 359-364 (2003) :
Nguyen, V.T., et al. J. Biol. Chem. 275(38):29466-29476(2000)
Morgan, R.O., et al. Gene 227(1):33-38(1999)
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