癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SERINC3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q13530 |
| Other Accession | Q9QZI9, NP_945179.1, NP_006802.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52580 Da |
| Antigen Region | 373-400 aa |
| Gene ID | 10955 |
|---|---|
| Other Names | Serine incorporator 3, Tumor differentially expressed protein 1, SERINC3, DIFF33, TDE1 |
| Target/Specificity | This SERINC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-400 amino acids from the C-terminal region of human SERINC3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SERINC3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERINC3 (HGNC:11699) |
|---|---|
| Function | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP-dependent, non- specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity (PubMed:37474505). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9QZI9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9QZI9} |
| Tissue Location | Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SERINC3 may be involved in cellular transformation.
REFERENCES
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Bossolasco, M., et al. Oncogene 25(33):4549-4558(2006)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Bossolasco, M., et al. Mol. Carcinog. 26(3):189-200(1999)
Adams, M.D., et al. Nature 377 (6547 SUPPL), 3-174 (1995) :
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