IFIT2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application ![]()
| WB, E |
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Primary Accession | P09913 |
Other Accession | NP_001538.4 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 54632 Da |
Antigen Region | 307-335 aa |
Gene ID | 3433 |
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Other Names | Interferon-induced protein with tetratricopeptide repeats 2, IFIT-2, ISG-54 K, Interferon-induced 54 kDa protein, IFI-54K, P54, IFIT2, CIG-42, G10P2, IFI54, ISG54 |
Target/Specificity | This IFIT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the Central region of human IFIT2. |
Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | IFIT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IFIT2 |
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Synonyms | CIG-42, G10P2, IFI54, ISG54 |
Function | IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. |
Cellular Location | Cytoplasm. Endoplasmic reticulum |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Lai, K.C., et al. Mol. Cancer Res. 6(9):1431-1439(2008)
Terenzi, F., et al. J. Biol. Chem. 281(45):34064-34071(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Saha, S., et al. J. Gen. Virol. 87 (PT 11), 3285-3289 (2006) :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)

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