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IFIT2 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - IFIT2 Antibody (Center) AP17102c
    IFIT2 Antibody (Center) (Cat. #AP17102c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the IFIT2 antibody detected the IFIT2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P09913
Other Accession NP_001538.4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 54632 Da
Antigen Region 307-335 aa
Additional Information
Gene ID 3433
Other Names Interferon-induced protein with tetratricopeptide repeats 2, IFIT-2, ISG-54 K, Interferon-induced 54 kDa protein, IFI-54K, P54, IFIT2, CIG-42, G10P2, IFI54, ISG54
Target/Specificity This IFIT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the Central region of human IFIT2.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIFIT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFIT2
Synonyms CIG-42, G10P2, IFI54, ISG54
Function IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
Cellular Location Cytoplasm. Endoplasmic reticulum
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

Lai, K.C., et al. Mol. Cancer Res. 6(9):1431-1439(2008)
Terenzi, F., et al. J. Biol. Chem. 281(45):34064-34071(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Saha, S., et al. J. Gen. Virol. 87 (PT 11), 3285-3289 (2006) :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)

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