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GPR97 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q86Y34 |
| Other Accession | NP_740746.4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60861 Da |
| Antigen Region | 103-130 aa |
| Gene ID | 222487 |
|---|---|
| Other Names | Probable G-protein coupled receptor 97, G-protein coupled receptor PGR26, GPR97, PGR26 |
| Target/Specificity | This GPR97 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-130 amino acids from the N-terminal region of human GPR97. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR97 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADGRG3 {ECO:0000303|PubMed:30559745, ECO:0000312|HGNC:HGNC:13728} |
|---|---|
| Function | Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11- deoxycortisol (PubMed:33408414). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:33408414). ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity (PubMed:33408414). May also signal through G-alpha(q)- proteins; additional evidence are however required to confirm this result in vivo (PubMed:22575658). Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity (PubMed:30559745, PubMed:36302784). Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and myeloperoxidase (MPO) as well as enhanced bacteria uptake and killing by granulocytes (PubMed:30559745). Additionally, collaborates with protease-activated receptor 2/PAR2 to stimulate neutrophil-driven antimicrobial responses and endothelial cell activation (PubMed:36302784). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in cultured primary dermal lymphatic endothelial cells (PubMed:24178298). Highly expressed in polymorphonuclear cells (PMNs) including neutrophilic, eosinophilic, and basophilic granulocytes (PubMed:30559745) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GPR97 is an orphan receptor.
REFERENCES
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Bjarnadottir, T.K., et al. Genomics 84(1):23-33(2004)
Vassilatis, D.K., et al. Proc. Natl. Acad. Sci. U.S.A. 100(8):4903-4908(2003)
Fredriksson, R., et al. FEBS Lett. 531(3):407-414(2002)
Kuznicki, J., et al. Cell Biol. Int. Rep. 3(1):17-23(1979)
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¥ 1,250.00
Cat# AP17125a
