癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TRIM68 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
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Application 
| WB, E |
|---|---|
| Primary Accession | Q6AZZ1 |
| Other Accession | NP_060543.5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56259 Da |
| Antigen Region | 382-411 aa |
| Gene ID | 55128 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM68, 632-, RING finger protein 137, SSA protein SS-56, SS-56, Tripartite motif-containing protein 68, TRIM68, GC109, RNF137, SS56 |
| Target/Specificity | This TRIM68 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 382-411 amino acids from the C-terminal region of human TRIM68. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM68 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM68 |
|---|---|
| Synonyms | GC109, RNF137, SS56 |
| Function | Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. |
| Cellular Location | Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus |
| Tissue Location | Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.
REFERENCES
Malhotra, A., et al. Diabetes Metab. Res. Rev. 25(8):740-747(2009)
Miyajima, N., et al. Cancer Res. 68(9):3486-3494(2008)
Chang, G.T., et al. Eur. J. Cancer 37(16):2129-2134(2001)
Billaut-Mulot, O., et al. J. Clin. Invest. 108(6):861-869(2001)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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