癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RHD Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q02161 |
| Other Accession | NP_001121163.1, NP_057208.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45211 Da |
| Antigen Region | 173-201 aa |
| Gene ID | 6007 |
|---|---|
| Other Names | Blood group Rh(D) polypeptide, RHXIII, Rh polypeptide 2, RhPII, Rhesus D antigen, CD240D, RHD |
| Target/Specificity | This RHD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-201 amino acids from the Central region of human RHD. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RHD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RHD |
|---|---|
| Function | May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Restricted to tissues or cell lines expressing erythroid characters |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Flegr, J., et al. Folia Parasitol. 57(2):143-150(2010)
Liu, H.C., et al. Biochim. Biophys. Acta 1800(6):565-573(2010)
Schmid, P., et al. Transfusion 50(1):267-269(2010)
Wang, X.D., et al. Eur. J. Clin. Invest. 39(7):607-617(2009)
Wagner, F.F., et al. Blood 99(6):2272-2273(2002)
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