癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TH1L Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IXH7 |
| Other Accession | A5GFY4, NP_945327.1 |
| Reactivity | Human |
| Predicted | Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 66247 Da |
| Antigen Region | 548-576 aa |
| Gene ID | 51497 |
|---|---|
| Other Names | Negative elongation factor C/D, NELF-C/D, TH1-like protein, NELFCD, NELFD, TH1, TH1L |
| Target/Specificity | This TH1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-576 amino acids from the C-terminal region of human TH1L. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TH1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NELFCD |
|---|---|
| Synonyms | NELFD, TH1, TH1L |
| Function | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.
REFERENCES
Zou, W., et al. Cancer Sci. 101(10):2156-2162(2010)
Yang, Y., et al. J. Cell. Biochem. 109(5):1013-1024(2010)
Sun, J., et al. J. Biol. Chem. 285(9):6443-6452(2010)
Pal, P., et al. Croat. Med. J. 50(4):361-369(2009)
Cheng, C., et al. J. Biol. Chem. 284(13):8786-8796(2009)
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