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PITPNM1 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O00562 |
| Other Accession | NP_004901.2, NP_001124320.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 134848 Da |
| Antigen Region | 143-171 aa |
| Gene ID | 9600 |
|---|---|
| Other Names | Membrane-associated phosphatidylinositol transfer protein 1, Drosophila retinal degeneration B homolog, Phosphatidylinositol transfer protein, membrane-associated 1, PITPnm 1, Pyk2 N-terminal domain-interacting receptor 2, NIR-2, PITPNM1, DRES9, NIR2, PITPNM |
| Target/Specificity | This PITPNM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-171 amino acids from the N-terminal region of human PITPNM1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PITPNM1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PITPNM1 (HGNC:9003) |
|---|---|
| Synonyms | DRES9, NIR2, PITPNM |
| Function | Membrane-associated phosphatidylinositol (PI) transfer protein that shuttles PI between intracellular membranes and thereby maintains plasma-membrane phosphoinositide signaling competence (PubMed:10531358, PubMed:22822086, PubMed:25887399, PubMed:26028218, PubMed:41129229). Transfers phosphatidylinositol from the endoplasmic reticulum to the plasma membrane and mediates counter-transport of phosphatidic acid (PA) from the plasma membrane to the endoplasmic reticulum at endoplasmic reticulum-plasma membrane contact sites, this PI/PA exchange is required for sustained PLC-coupled receptor signaling and for replenishment of plasma membrane phosphoinositide following receptor-induced hydrolysis (PubMed:10531358, PubMed:22822086, PubMed:26028218). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:11909959, PubMed:15545272, PubMed:15723057). |
| Cellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet. Cleavage furrow. Midbody Note=Upon PIP2 hydrolysis, translocates to endoplasmic reticulum-plasma membrane contact sites (PubMed:25887399). Peripheral membrane protein associated with Golgi stacks in interphase cells. Associated with lipid droplets (PubMed:12225667). Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (PubMed:15125835). |
| Tissue Location | Ubiquitous.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).
REFERENCES
Burgis, N.E., et al. J. Biol. Chem. 282(6):3531-3538(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Litvak, V., et al. Nat. Cell Biol. 7(3):225-234(2005)
Amarilio, R., et al. J. Biol. Chem. 280(7):5934-5944(2005)
Ocaka, L., et al. Cytogenet. Genome Res. 108(4):293-302(2005)
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¥ 1,250.00
Cat# AP17243a
