癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ESX1 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q8N693 |
| Other Accession | NP_703149.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44297 Da |
| Antigen Region | 28-55 aa |
| Gene ID | 80712 |
|---|---|
| Other Names | Homeobox protein ESX1, Extraembryonic, spermatogenesis, homeobox 1, Homeobox protein ESX1-N, Homeobox protein ESX1-C, ESX1, ESX1L, ESX1R |
| Target/Specificity | This ESX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-55 amino acids from the N-terminal region of human ESX1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ESX1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ESX1 |
|---|---|
| Synonyms | ESX1L, ESX1R |
| Function | May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584} Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm |
| Tissue Location | Expressed in placenta and testis. Expressed in testicular germ cell tumors. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.
REFERENCES
Bonaparte, E., et al. Hum. Reprod. 25(6):1398-1403(2010)
Wang, X., et al. Hum. Mol. Genet. 16(17):2053-2060(2007)
Loschiavo, M., et al. Mamm. Genome 18(1):75-85(2007)
Murthi, P., et al. Mol. Hum. Reprod. 12(5):335-340(2006)
Yanagihara, M., et al. Oncogene 24(38):5878-5887(2005)
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