癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Stk39 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Z1W9 |
| Other Accession | NP_058562.1 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60320 Da |
| Antigen Region | 433-460 aa |
| Gene ID | 53416 |
|---|---|
| Other Names | STE20/SPS1-related proline-alanine-rich protein kinase, Ste-20-related kinase, Serine/threonine-protein kinase 39, Stk39, Spak |
| Target/Specificity | This Mouse Stk39 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 433-460 amino acids from the C-terminal region of mouse Stk39. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Stk39 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Stk39 |
|---|---|
| Function | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Specifically recognizes and binds proteins with a RFXV motif (PubMed:14563843). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:14563843, PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (By similarity). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (By similarity). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (PubMed:21317537, PubMed:23542070). Phosphorylates RELT (PubMed:16530727). |
| Cellular Location | Cytoplasm. Nucleus. Apical cell membrane. Note=Nucleus when caspase-cleaved. In choroid plexus cells, found at the apical plasma membrane of epithelial cells (PubMed:14563843) {ECO:0000269|PubMed:14563843, ECO:0000305} |
| Tissue Location | Expressed in the kidney, including in epithelial cells of the thick ascending limb of Henle's loop and in the distal convoluted tubule (at protein level) (PubMed:20385770). Expressed at high levels in the brain, but only in the brainstem (at protein level) Expressed in the spinal chord, where it is expressed in neurons as well as in glial cells, and sciatic nerve, in the nodes of Ranvier (at protein level). Also detected in lung, liver, stomach and salivary glands (at protein level) (PubMed:14563843) [Isoform 2]: Restricted to kidney. Not detected in brain. In the kidney, may be expressed at higher levels in the thick ascending limb compared to the distal convoluted tubule (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Stk39 may act as a mediator of stress-activated signals.
REFERENCES
Yang, S.S., et al. J. Am. Soc. Nephrol. 21(11):1868-1877(2010)
Gagnon, K.B., et al. Am. J. Physiol., Cell Physiol. 299 (3), C614-C620 (2010) :
Sid, B., et al. J. Physiol. (Lond.) 588 (PT 13), 2315-2328 (2010) :
Reiche, J., et al. Mol. Cell. Biol. 30(12):3027-3037(2010)
Hengl, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(13):6052-6057(2010)
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