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FUNDC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 2
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IVP5 |
| Other Accession | Q5BJS4, Q9DB70, F1N5S9, NP_776155.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17178 Da |
| Antigen Region | 79-108 aa |
| Gene ID | 139341 |
|---|---|
| Other Names | FUN14 domain-containing protein 1, FUNDC1 |
| Target/Specificity | This FUNDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the N-terminal region of human FUNDC1. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FUNDC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FUNDC1 |
|---|---|
| Function | Integral mitochondrial outer-membrane protein that mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:33972548). In turn, mediates angiogenesis and neoangiogenesis through interference with intracellular Ca(2+) communication and regulation of the vascular endothelial growth factor receptor KDR/VEGFR2 expression at both mRNA and protein levels (PubMed:33972548). Also acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality and homeostasis, by interacting with and recruiting LC3 protein family to mitochondria (PubMed:22267086, PubMed:24671035, PubMed:24746696, PubMed:27653272). Mechanistically, recruits DRP1 at ER-mitochondria contact sites leading to DRP1 oligomerization and GTPase activity to facilitate mitochondrial fission during hypoxia (PubMed:27145933, PubMed:33978709). Additionally, plays a role in hepatic ferroptosis by interacting directly with glutathione peroxidase/GPX4 to facilitate its recruitment into mitochondria through TOM/TIM complex where it is degraded by mitophagy (PubMed:36828120). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed.. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FUNDC1 belongs to the FUN14 family. The exact function of FUNDC1 remains unknown.
REFERENCES
Terracciano, A., et al. Mol. Psychiatry 15(6):647-656(2010)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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Cat# AP17377a
